ORTHOVISC is a high molecular weight viscosupplement successfully used for more than 20 years in treating pain caused by osteoarthritis.

ORTHOVISC ADVANTAGES

• In use for more than 20 years
• No animal origin in HA
• Strong, long-lasting pain relief for a period of 6 months[12]
• May delay the need for a knee replacement procedure by up to 3.6 years[13]
• No confirmed pseudoseptic reactions[14]
• FDA approved
• HA concentration 2ml/30mg

MOLECULAR WEIGHT SUBSTANCES
Due to the optimal molecular weight, it strongly binds to cell surface receptors[5,15,16]

Link: https://www.anikatherapeutics.com/products/pain_management/orthovisc/

[5] Smith MM, Ghosh P. The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol Int. 1987; 7(3):113-22.

[12] Brandt KD, Block JA, Michalski JP, Moreland LW, Caldwell JR, Lavin PT. Ecacy and safety of intra-articular sodium hyaluronate in knee osteoarthritis. ORTHOVISC Study Group. Clin Orthop Relat Res 2001;(385):130 – 43.

[13] Altman, R., et. al. Hyaluronic Acid Injections Are Associated with Delay of Total Knee Replacement Surgery in Patients with Knee Osteoarthritis: Evidence from a Large U.S. Health Claims Database. 2015 Dec; doi 10.1371/journal.pone.0145776.

[14] Information from package inserts.

[15] Tobetto K, Yasui T, Ando T, et al. Inhibitory eects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts. Jpn J Pharmacol. 1992 Oct;60(2):79-84.

[16] S Gotoh, J Onaya, et al. Eects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats, Ann Rheum Dis 1993;52;817-822.

MONOVISC

MONOVISC is a highly concentrated cross-linked hyaluronic acid viscosupplement used to relieve pain caused by osteoarthritis.
MONOVISC is produced from ultra-pure sodium hyaluronate, a high molecular weight produced by bacterial fermentation.

#1 VISCOSUPPLEMENT in the USA.

MONOVISC is FDA approved, MONOVISC & ORTHOVISC are the most prescribed viscosupplements in the USA.

Why MONOVISC?

• Convenient single injection treatment
• Highest dose of HA (88mg)
• FDA approved
• No animal origin
• Provides strong and proven long-lasting pain relief of up to 26 weeks[7,8]
• More than a million apps worldwide
• Safely used for more than 10 years

CLINICALLY PROVEN PAIN RELIEF IN 6 MONTHS

• MONOVISC 65% improvement in WOMAC pain score at 26 weeks, compared to baseline (p = 0.0352)[10]
• MONOVISC 85% improvement in OMERACT-OARSI Index over 26 weeks[6]
• MONOVISC clinically significant reduction in osteoarthritis knee pain within 2 weeks of injection[11]

Link: https://www.anikatherapeutics.com/products/pain_management/monovisc/

[6] CINGAL 13- 01, a randomized, double-blind, placebo-controlled, active comparator Phase 3 study.

[7] Clinical Ecacy and Safety of MONOVISC™: A lightly cross-linked highly concentrated hyaluronan specially formulated for single injection in osteoarthritis. White Paper Study conducted by Michael J. Daley, PhD. 2013

[8] Post-Approval Study of MONOVISC®, A Symptomatic Treatment of Osteoarthritis, White Paper, 2012.

[9] Information from package inserts.

[10] Hangody L, Szody R, Lukasik P, et al. Cartilage 2017 May; doi:10.1177/1947603517703732.

[11] Petterson SC, Plancher KD. Knee Surg Sports Traumatol Arthrosc (2018). https://doi.org/10.1007/s00167-018-5114-0

C1⁺NGAL

CINGAL is the first and only approved viscosupplement that represents a combination of cross-linked hyaluronic acid (HA) and the fast-acting corticosteroid Triamcinolone Hexacetonide (TH) for the long-term elimination of osteoarthritis symptoms, approved by the FDA.

The corticosteroid reduces inflammation in the knee joint, providing rapid pain relief after injection, with the hyaluronic acid component providing long-term pain relief, proven to last for 6 months[1].

The corticosteroid Triamcinolone Hexacetonide (TH) acts rapidly on the inflammatory process [2,3]

TH reduces the production of destructive inflammatory cytokines and reduces their harmful effect[2,3]

Why CINGAL?

• Two-component therapy 88mg HA/18mg TH
• High in HA concentration
• Proven pain relief for 6 months[1]
• Safe and efficient
• No animal origin
• Convenient 1 injection treatment
• Improves mobility and joint protection

CINGAL WAS CLINICALLY PROVEN AS A FAST AND LONG-TERM RELIEF FROM OSTEOARTHRITIS PAIN

• Improvement of CINGAL of 59% on the WOMAC scale in the first week (p = 0.008)[1]
• Improvement of CINGAL of 72% on the WOMAC scale in week 26 (p = 0.0027)[1]
• Improvement of CINGAL of 89% according to OMERACT-OARSI index during the first week (p = 0.0161)[1]
• Improvement of CINGAL of 92% according to OMERACT-OARSI index during 26 weeks period (p = 0.0100)[6]

Link: https://www.cingal.com/

[1] Hangody L., et al. Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee. Cartilage 2017 May; doi: 10.1177/1947603517703732.

[2] Creamer P. Intra-articular corticosteroid injections in osteoarthritis: do they work and if so, how? Ann Rheum Dis. 1997;56(11):634-636.

[3] Nicholls M.A., et. Al. The Disease-Modifying Eects of Hyaluronan in the Osteoarthritic Disease State. Clin Med Insights Arthritis Musculoskelet Disord. 2017; 10:1179544117723611.

[6] CINGAL 13- 01, a randomized, double-blind, placebo-controlled, active comparator Phase 3 study.

Original Serrapeptase cream

The original Serrapeptase cream, with its optimal pH, enables the full effect of the serrapeptase enzyme, comfrey extract (10%), panthenol, and aloe. Its original composition enables full effectiveness for swelling, hematoma, and muscle pain, after fractures, and sports injuries.

Serrapeptase is a very strong biological anti-inflammatory agent.

Serrapeptase assimilates lifeless tissue, blood clots and the aforementioned inflammation in all its forms. The best is the strongest natural anti-inflammatory preparation that does not have any side effects.
Serrapeptase is a biological compound used as an anti-inflammatory agent, applied in anti-inflammatory cases that has analgesic and anti-edematous effects.

Comfrey extract (lat. Syntphytum officinaleand) relieves pain, inflammation and muscle swelling in joints in diseases such as degenerative arthritis, dislocations and sprains, as well as in sports injuries and strains. Using comfrey relieves pain associated with fibromyalgia.

The original Serrapeptase cream with 10% comfrey root extract has a beneficial effect on:

• swelling
• hematoma
• muscle pain
• sports injuries
• post-traumatic conditions.

As a natural skin ingredient and active substance, panthenol increases the amount of water in the surface layers of the skin, providing skin moisture, softness and restoring skin elasticity. Panthenol has an epithelizing effect and regenerative properties.

The natural extract of Aloe Barbadensis has a beneficial effect and provides sensitive and dry skin with complete hydration and moisture, and a cooling effect. It makes the skin stronger and hydrated. It has a mild soothing effect on swollen and inflamed skin.

Recommenden use:
Apply the cream in a thin layer to the desired place on the skin 3-4 times a day and gently rub it in

Caution:
For external use only.