C1+NGAL

FAST ACTING. LONG LASTING.

CINGAL is the first and only approved viscosupplement that represents a combination of cross-linked hyaluronic acid (HA) and the fast-acting corticosteroid Triamcinolone Hexacetonide (TH) for the long-term elimination of osteoarthritis symptoms, approved by the FDA.

The corticosteroid reduces inflammation in the knee joint, providing rapid pain relief after injection, with the hyaluronic acid component providing long-term pain relief, proven to last for 6 months[1].

The corticosteroid Triamcinolone Hexacetonide (TH) acts rapidly on the inflammatory process [2,3]

TH reduces the production of destructive inflammatory cytokines and reduces their harmful effect[2,3]

Why CINGAL?

  • Two-component therapy 88mg HA/18mg TH
  • High in HA concentration
  • Proven pain relief for 6 months[1]
  • Safe and efficient
  • No animal origin
  • Convenient 1 injection treatment
  • Improves mobility and joint protection

CINGAL WAS CLINICALLY PROVEN AS A FAST AND LONG-TERM RELIEF FROM OSTEOARTHRITIS PAIN

  • Improvement of CINGAL of 59% on the WOMAC scale in the first week (p = 0.008)[1]
  • Improvement of CINGAL of 72% on the WOMAC scale in week 26 (p = 0.0027)[1]
  • Improvement of CINGAL of 89% according to OMERACT-OARSI index during the first week (p = 0.0161)[1]
  • Improvement of CINGAL of 92% according to OMERACT-OARSI index during 26 weeks period (p = 0.0100)[6]

Link: https://www.cingal.com/

[1] Hangody L., et al. Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee. Cartilage 2017 May; doi: 10.1177/1947603517703732.
[2] Creamer P. Intra-articular corticosteroid injections in osteoarthritis: do they work and if so, how? Ann Rheum Dis. 1997;56(11):634-636.
[3] Nicholls M.A., et. Al. The Disease-Modifying Eects of Hyaluronan in the Osteoarthritic Disease State. Clin Med Insights Arthritis Musculoskelet Disord. 2017; 10:1179544117723611.
[6] CINGAL 13- 01, a randomized, double-blind, placebo-controlled, active comparator Phase 3 study.

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